On the Path to Victory
Brain Reward™
A Course Correction for Your Mind

Brain Reward™ nutritionally supports the ability to experience reward benefits from normal activities, especially in people with Reward Deficiency Syndrome who have greater difficulty achieving satisfaction from normally rewarding thoughts, experiences, and ingested foods and beverages. Among its other benefits, the patented nutritional formula in Brain Reward™ has been shown to:

  • Support Dopamine sensitivity and function
  • Help Regulate Cravings
  • Improve Recovery
  • Improve Energy and Detox
  • Relieve Stress
  • Support focus, concentration, and cognition
  • Support optimal brain health, elevated mood, weight management, overall wellness and vitality
The Dopamine Fix

People with reward deficiencies experience an imbalance in their brain reward chemistry that impairs the function of one or more of the multiple steps in the brain reward cascade (starting with serotonin and going down to dopamine) that can lead to dopamine deficits, dopamine resistance, loss of pleasure, increased stress, and reduced focus, concentration, cognition, and even unhappiness. This prompts individuals to engage in a wide range of intensified reward seeking thoughts and experiences to get that pleasurable 'dopamine fix.' People with reward deficiencies often engage in excessive 'reward seeking' behaviors to temporarily get their 'dopamine fix' and satisfy their immediate reward needs, often resulting in unhealthy and even dangerous outcomes.

Nutrigenomic Neuroadaptogen Technology

Brain Reward™ uses the patented and patent pending KB220Z Nutrigenomic technology for optimal brain health and focus; to enhance energy, relieve stress, help regulate cravings, and to support mood resulting in a sense of well-being.

True Mind and Body Wellness has Arrived

If you or a loved one is grappling with consequences of stress, chronic unhappiness, or the excessive pursuit of pleasure-inducing activities, substances, or thoughts, or if you just want to increase your willpower and self-control, improve your energy, and achieve a happier fulfilling life, get started on Brain Reward™ now.




'KB220Z Nutrigenomic Neuroadaptogen' is the current research code for the nutraceutical technology called Endorphamine® in the Brain Reward™ formula. However, over the years, other names and/or research codes for the same technology have been used such as SG8839, LG839, Synaptamine, Haveos, SAAVE, PCAL-I03, KB220, etc. All of these names and/or codes are for research on the patented and patent-pending foundational technology as it has evolved, been added to, and culminated in the present KB220Z technology.

Chronological Summary of KB220 Research


QHow do we know Brain Reward™ is safe?

AFirst, most of the ingredients are GRAS (Generally Recognized As Safe). GRAS is a regulatory safety status of ingredients that have earned it by enduring a rigorous review process to ensure the products safe use in foods and beverages. That some ingredients don't have this status doesn't mean that they are unsafe. It means that they just haven't been subjected to the scientific review process, most probably because they are not candidates for food and beverage applications. Second, the entire formula has been the subject of numerous studies, both animal and human, many of which also investigate whether any toxic or adverse effects are exhibited in the study subjects. There have been no reports of any statistically significant toxic or adverse effects in animal studies, pilot studies, clinical case studies, or major peer reviewed research.

QWhat makes Brain Reward™ unique and superior to other dietary supplements?

AMost of the ingredients selected are premium quality (and expensive) proprietary, trademarked, branded, and evidence-based ingredients or ingredient complexes. Brain Reward™ contains the branded ingredient complex, Endorphamine®, a KB220Z nutraceutical neuroadaptogen complex, which is exclusive to Brain Reward. Moreover, Brain Reward™ goes through a 3-step Quality verification process using Fourier Transform Infrared (FTIR) analysis. FTIR analysis produces a sort of energetic fingerprint or signature that must match that of its validated reference standard. If it fails this test, it is rejected. The ingredients undergo FTIR analysis individually. The finished Brain Reward product is then Prodosomed, which again undergoes FTIR to ensure that it has maintained the integrity of the ingredient complex. We have been fortunate in selecting the best ingredients (needed to make the best product) and have not had any problems to date. Importantly, no other dietary supplement formulation has EVER come to market backed by 29 clinical studies, like Brain Reward™.

QIs Brain Reward™ different from weight loss products in how it works to promote a reduction in excess body fat?

AThe simple answer is a categorical 'YES!' The longer (and more accurate) explanation is that Brain Reward™ is not actually a 'weight loss' product in the truest meaning of the term. While Brain Reward™ does have a positive impact on body composition, it uses entirely different and ESSENTIAL mechanisms to nutritionally support a healthy mind and body, and positively affect energy metabolism, cravings, stress reduction, neuroendocrine function, immune function, and ultimately, body composition. Contrary to popular perceptions (and dogma), getting rid of excess stored fat is not really about 'weight loss.' The actual meaning of the term 'Weight Loss' is to 'reduce heaviness'. Targeting this objective misses the root cause of WHY some people continue to store ever increasing amounts of fat. Importantly, the tactics used in this most common traditional approach not only do NOT solve the problem, but appear to increase the progressive severity of the problem.

This is why 100% of the weight loss products and programs fail more than 95% of the time in 2 to 5 years. With more than 6 decades of weight loss tactics, products, and programs, the overwhelming evidence indicates that conventional strategies to 'lose weight' are not working. The vast majority of these strategies have used 1 or more of the following types of failed tactics to reduce heaviness:

  1. Deprivation: Reducing the intake or impact of calories by various mechanisms (i.e. appetite suppressants, fat blockers, starch blockers, water absorbing fiber-water-fill-you-up pre-meal bulking agents, etc.). Collectively these tactics are called 'Deprivation' because they are intended to deprive the body of caloric impact and the supposed consequential fat (weight) gain caused by those calories.
  2. Stimulation: Stimulating fat burning or the central nervous system to burn more calories than are taken in. There are many nutraceutical products that exert this kind of action (i.e. synephrine, caffeine, cola nut, guarana, salicylic acid, DMAA, Yohimbine, etc.).
  3. Excessive Exercise: This is most often also used to burn more calories than are consumed.
  4. Elimination: Promoting aggressive urinary and/or bowel elimination by various kinds of aggressive fibers, diuretics, and laxatives, etc.

Note: Fat is 'survival energy' insurance. As such, ALL of these tactics, alone or in combination work against the body's mandated genetic survival defense system, which ultimately increases 'survival panic' and causes a defensive response to these forceful tactics by: 1. Turning down cellular energy production (for energy conservation, a.k.a 'survival'), 2. Increasing fat storage (fat is survival insurance, i.e. also energy conservation), and 3. Increasingcravings to increase food (energy) consumption.

Conventional dogma states that people are fat because 'they eat too much and don't exercise enough'...and we categorically accept this dogma because it seems logical. However, if this was the actual reason, then everyone who ate less and exercised more would be thinner (or lighter) than everyone who didn't, and we know this is NOT the case. There are 3 primary causes of ill health, including obesity and other conditions:

  1. Poor lifestyle choices: This includes taking in not enough of the good stuff that keeps us healthy (i.e. nutritional deficiencies, etc.); and getting too much of the bad stuff that makes us unhealthy (i.e. toxic chemical & environmental pollutants, EMFs, etc.).
  2. (Dis)Stress: Excessive stressful burdens contribute to 'too much of the bad' in #1 immediately above.
  3. Genetic predispositions: Genetic predispositions are a major contributor to Reward Deficiency Syndrome behaviors (more on this later). We can't change our genes, but we can change ('make a corrective adjustment' ala 'Optimize') our Gene Expression.

Epigenetics is the science that studies how lifestyle choices influence gene expression and overall health. Nutrigenomics is the science within Epigenetics that studies how nutritional choices affect gene expression and how that influences overall health.

So, the issue is not that fat people eat too much and don't exercise enough; the question is 'WHY'? Obesity and overweight are a 'deficient energy' and metabolic regulation crisis (not just a heaviness crisis), which requires a nutri-genetic (nutrigenomic) approach to promoting optimal brain function. What is required is correcting the gene expression and metabolic retardation that caused excessive energy conservation (from survival panic), which turned down energy production (in the muscles...aka 'muscle sluggishness' and fatigue), increased fat storage, and increased cravings (both in the brain and at the cellular level). Anything that induces survival panic, like excessive stress, nutrient deficiencies, and toxic load, ultimately cause energy conservation and fat gain. This is especially relevant in people who have genetic predispositions in the reward and survival centers of the brain that results in a much more aggressive response to such factors.

Brain Reward™ works by replenishing the nutritional needs of the Brain Reward Cascade (BRC), relieving stress, and optimizing gene expression in the BRC; addressing all 3 factors that contribute to reduced health. Moreover, because Brain Reward™ nutritionally relieves 'survival panic', it thereby allows the body to turn on permissible energy expenditure, regulate cravings (reduce & change), promote neuroendocrine competence, and bolster immune strength. This is what is first required for the body to let go of excess fat, ala 'survival insurance' and improve sustainable lean body composition.

QLast year I had to lose about 25 pounds to fit into a dress for an upcoming wedding. I had two months to lose the weight. I took a weight loss product, went on a fasting program, and started an aggressive exercise regimen. I lost the weight and got into that dress. I looked great and enjoyed the tremendous satisfaction from my achievement! Since then, I've gained back about 5 more pounds than I lost. Can't I just go back on that program again?

ADon't do it! (I guess that's not enough of an answer.) Rapid weight loss programs, especially a chain of numerous repetitions of those programs, literally wreak havoc on the body's survival security system, which disrupts energy regulation by throwing the body into a panicked state of extreme energy conservation (resulting in increased fat storage, fatigue, and excess cravings). Rapid weight loss programs may be a greater contributor to the obesity epidemic, especially for those with genetic predispositions, than that caused by poor diet alone.

QI've done a lot of weight loss programs. They all seem to work to some extent in the beginning. But, after a few weeks my weight loss plateaus and even begins to creep back up, even though I stay on the program even with a vigorous exercise regimen. Why?

AThis is one of the most common occurrences with weight loss programs. Recall that research indicates 100% of weight loss programs fail more than 95% of the time in 2 to 5 years. However, very often continued compliance in the early weeks of a program is poor exactly for the reasons you indicate. People see the 'scale weight' losses level off and stay at the same number for a while (the 'plateau') and then start to creep back up again, oftentimes surpassing the weight at which they started the program even those that are engaging in vigorous exercise programs. This is called 'Yo-Yo rebound weight gain' or just a 'Yo-Yo diet'. Because of the genetic survival defense, they often gain more 'fat' weight back than was originally lost. They get so disappointed and just quit their program in defeat. There are reasons for this. However, some healthy 'weight gain' is entirely predictable.

Even when the weight loss program is healthy by any standards, there are some factors that frustrate 'weight loss' efforts (that is 'reducing heaviness') based on the bathroom scale. Fat is lighter than water, muscle, and bone; fat is the lightest of these macromolecules. Muscle cells are the primary and most abundant energy factories in the body. When the body is in a state of chronic survival distress, it goes into a state of energy conservation (see the first Question), which programs a 'down regulation' (reduction) in the muscle cells' ability to make energy; the muscle cells essentially try to go into a dormant state - a sort of muscle cell atrophy. The body just doesn't want to make (expend) energy; it wants to conserve energy. The body also increases fat storage and food (energy) cravings. Not surprisingly, along with the increase in cravings & food consumption, fatigue can also increase, which reduces the desire to be active (more energy conservation) even creating the appearance of laziness.

When the body once again allows itself to start making energy, it 'kick starts' energy production, which initially causes an increased elimination of excess water and CO2 (carbon dioxide), the byproducts of energy production. Since water is heavier than fat (and takes up more volume [size]), you see a reasonably quick reduction in heaviness (weight) and a modest reduction in size (the 'Yippee response'). But, eventually the body needs to restore a much greater ability to make more energy and starts rebuilding the nearly dormant energy factories in the muscle cells (mitochondria), which causes a mild increase in heaviness (because muscle is heavier than the fat and water that was lost). But, you generally don't see an increase in size, because muscle takes up a lot less space (volume) for the increased heaviness that results. But, most people (even professionals) don't understand this natural process, get frustrated and disappointed by the weight plateau and gains. It is common for the individual to get more aggressive with increased calorie deprivation, stimulation, and elimination tactics, and maybe increased intensity of their exercise regimen, the result of which reinstates' survival panic, and the Yo-Yo rebound weight gain process starts again and gains fat & water storage momentum.

So, since muscle is heavier than fat, "losing weight" is an inaccurate measurement of what can happen during the process of improving lean body composition. The weight scale may initially decrease (from water loss), then slightly increase (from muscle weight gain), then, decrease (when enough fat and water are lost to offset the heavier muscle weight gains). When this process has got some momentum, the weight scale gradually goes down, but size has already been decreasing, even if (muscle) weight has increased a bit. The message: Stay off the scale!

QI've been told that if we just have a healthy balanced diet and engage in moderate exercise, we will lose weight and be healthy. Is this true?

AIn general, it is mostly true. But, there are some flaws to that thinking for a number of reason. The first concerns the definition of a healthy balanced diet. We cannot delve into this particular aspect in any great depth here. But, suffice it to say that the questionable quality of foods in our markets is a serious concern, especially those produced by standard agribusiness factory farms and food processing technologies.

On a more relevant point, as mentioned in another answer, there are 3 main reasons people are unhealthy:

  1. Poor lifestyle choices: This includes taking in not enough of the good stuff that keeps us healthy (i.e. nutritional deficiencies, etc.); and getting too much of the bad stuff that makes us unhealthy (i.e. toxic chemical & environmental pollutants, EMFs, etc.).
  2. (Dis)Stress: Excessive stressful burdens contribute to 'too much of the bad' in #1 immediately above.
  3. Genetic Predispositions: Genetic predispositions are a major contributor to Reward Deficiency Syndrome behaviors (more on this later). We can't change our genes, but we can change ('make a corrective adjustment' ala 'Optimize') our Gene Expression.

Over 30% of the US population carries a genetic predisposition that increases the susceptibility to greater consequences from stress and risk of excessive obsessive, compulsive, impulsive, and addictive behaviors. This particular genetic predisposition is the dopamine D2 receptor gene, Taq I A1 variant (called an 'allele' or polymorphism); generally it is referred to simply as the 'DRD2 A1 gene'. This is the 'reward gene' (also called 'the addiction gene') that was discovered by Kenneth Blum, Ph.D. and Ernest Noble, Ph.D. and reported in JAMA in 1990. By the way, the rate of obesity is just over 30% of Americans (not a coincidence that it is the same as the rate of obesity). People who carry this gene have 30% to 40% less dopamine D2 receptors. This causes dopamine resistance and an increased need for a pleasure satisfying 'dopamine fix', because dopamine is your happy, feel good, anti-stress, and will-power neurotransmitter (among others). People that carry this gene routinely have "Reward Deficiency Syndrome" because it takes much more dopamine stimulating thoughts, behaviors, and substances (like sugar, drugs, food, etc.) to produce enough dopamine just to feel good (or normal).

In these cases, even eating the so-called healthy diet most often doesn't provide enough nutritional support to answer the need for more dopamine satisfaction. Brain Reward™ is a patented KB220Z Nutrigenomic Neuroadaptogen (US Patents 6,132,724, 6,955,873, and EU Patent EPO979092) and provides the only known evidence-based natural and effective dopamine agonist, supported by 29 studies (to date) that nutritionally supports optimal dopamine sensitivity and function. Brain Reward™ balances the neurochemistry in the brain reward cascade, culminating with dopamine.

QCan I take Brain Reward™ at the same time as my other supplements?

ABrain Reward™ contains some special forms and specific amounts of amino acids that have been dose-calibrated to optimze the gene expression of and rebalance all the neurotransmitters and their functional relationships to each in the Brain Reward Cascade (BRC). If the supplements you are taking, or the food you are eating contain proteins or amino acids, then you will increase the possibility that these proteins or amino acids would compete for absorption and function, and interfere with or prevent the absorption, and/or work in opposition of each other once inside the cells. It is called 'competitive inhibition'. In effect, you could significantly diminish the benefits of either by taking them together, which would be a waste of money.

QI see that Brain Reward™ uses Prodosome encapsulation technology. Why is this better than 'regular' supplement delivery forms?

A.Various types of nutrients that go through the digestive process have different absorption sites and rates. Some nutrients are absorbed pretty fast and some take much longer. Moreover, digestive health and absorption rates vary between people. However, afte accidents, the number one reason for emergency room visits in the US is digestive problems...it is an epidemic. So, the Prodosome Encapsulation technology is designed to not rely on the need for digestive disintegration and dissolution of nutrient components, enabling them to gain rapid access to the blood stream and targeted tissues. All of the cells in the GI tract are phospholipid loving. The phospholipid-rich clustoidal multilamellar structures of the Prodosomal complex enables effortless absorption of the ingredient payload. The reports from the field indicate extremely rapid biological activity.

Preliminary data (submitted for publication) on the Prodosome technology suggests absorption and bioavailability of the ingredient payload in the blood within minutes from oral intake. 

QIsn't Phenylalanine, an ingredient in Brain Reward, a potential stimulant?

ANo. One of the roles of phenylalanine is as a building block for Dopamine. Dopamine is an anti-stress and reward neurotransmitter. This is why deficits in dopamine tend to lead to "excessive reward seeking behaviors" like for over indulging in food, alcohol, drugs, sex, gambling, etc Sufficient dopamine causes a feeling of satisfaction, contentment, and even happiness, not stimulation per se. There are over 40 years of research by world renowned neuro-psychopharmacologists, like Dr. Kenneth Blum, the father of psychiatric genetics, supporting the crucial roles of all the ingredients in Brain Reward.

QIs phenylalanine any relation to the diet drug Fen-Phen?

ANo relation whatsoever.

QAspartame breaks down into phenylalanine, aspartic acid, and methanol, which further breaks down into formaldehyde. Do we know the effect of adding additional phenylalanine to people already ingesting aspartame though diet drinks? Will this increase the danger of using aspartame? For those of who don't use any artificial sweeteners, how can we be assured that taking phenylalanine doesn't produce the same effects that aspartame does?

APhenylalanine is an essential amino acid. That means that if you don't put it into your mouth your body cannot make it and you will suffer the consequences of deficiencies. That also means that a different question needs to be asked. And, that is, "If taking the Brain Reward™ can reduce excess sugar craving, am I able to reduce the amount of "artificial" sweeteners that I use?" The answer is, "probably yes!" For the most part, artificial sweeteners have been chemically altered. The amino acids in Brain Reward™ are in their natural 'body-friendly' state, not chemically altered.